Update 3:47pm:
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The women has been freed from the vehicle.
Update 3:27pm:
A male passenger is being treated for a hip injury.
A female passenger is trapped in the vehicle.
Update 3:10pm:
The person trapped in the vehicle is being attended to by ambulance at the scene.
Traffic diversions are in place, with one lane open in each direction. There's a five minute delay with motorists advised to slow down and approach with caution.
Earlier:
There has been a two vehicle crash on Old Hume Highway and Alymerton Rd, southbound.
Emergency crews are on the scene, with reports of a person trapped.
Traffic in both directions is heavy.