The woman, 20, was on her way to work in Moss Vale when she came off the road on a long left hand bend 100 metres west of the Douglas Road intersection shortly after 7am.

Ingham employees were first on the scene and called triple 000 at 7.13am. Paramedics were unable to revive the unconscious driver and she was pronounced dead at 7.42am. She was the only person in the car.

The driver's side of the silver Hyundai Elantra was wrapped around the tree and the woman remained trapped for more than three hours before being taken out of the car.

Goulburn Highway Patrol supervisor Senior Sergeant John Kane said it was too early to say if speed played a factor but it appeared the woman lost control coming around the bend. The speed limit for the section of road is 80kmh.

Snr Sgt Kane said it was the second fatality in the Southern Region, which includes the Goulburn command and runs down to Wagga, after an 86-year-old woman was killed in Darkes Forest, north of Thirroul, after a two-vehicle accident on Thursday.

The Easter Road toll stands at three after a woman was killed in a head-on collision at Milperra on Saturday night.

Last Easter nine people died on NSW roads.

As of midnight Sunday there were 67 crashes in the Southern Region, 12 less than the same time last year, with 42 people injured, one less than 2009. There were no fatalities in the Southern Region last Easter.

Berrima Road remains closed in both directions while police investigate the crash.