A motorcycle rider has been flown to Liverpool Hospital following a head-on crash in Wildes Meadow.
According to a NSW Ambulance Media spokesman, the 28-year-old man is in a serious condition with an injury to his right leg.
Paramedics also treated a 25-year-old woman on the scene for grazes to the knee.
According to a NSW Rural Fire Service spokesman, the collision happened between a car and motorcycle on Myra Vale Road, Wildes Meadow.
The spokesman also said there were initially people trapped in the vehicle.
Two other people were assessed at the scene however they had "little to no injuries".
NSW Rural Fire Service crews, Southern Highlands Police, NSW Ambulance, NSW State Emergency Service crews and a tow truck driver assisted at the scene.