Emergency services and traffic crews have cleared the scene of crash.
A NSW Ambulance media spokesperson said paramedics assessed three people however no one was transported to hospital.
A crash between a truck and a car has caused delays for motorists on the Hume Highway.
The accident, which occurred just before 1pm on Sunday afternoon, took place at Sallys Corner Road at Sutton Forest.
The road is closed in a southbound direction while the emergency services and traffic crews work at the scene.
Southbound motorists can use the Sallys Corner Road off-ramp and then the Sallys Corner Road on-ramp to pass the crash location and return to the Hume Highway.
Motorists are advised to use diversions, allow extra travel time and exercise caution.