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A spokesman from the Bowral police station said SES were on the scene and no persons were trapped in the vehicles.
One lane is now open
No ambulance was on scene so it is believed there may be no injuries.
The spokesman said the cars caused some debris on the road which is being cleaned up by fire and rescue officers.
EARLIER:
Police and emergency services are attending to a two vehicle crash near the Medway off ramp at the Hume Highway, Berrima.
A spokesman from the Bowral Police said the call came through to police at 3:35pm.
He said one person may be trapped.
Details are as yet unknown.
More to come.